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Research in Dance and Physical Activity
[ Article ]
Research in Dance and Physical Activity - Vol. 7, No. 2, pp.87-98
ISSN: 2951-4770 (Online)
Print publication date 31 Aug 2023
Received 30 Jun 2023 Revised 25 Aug 2023 Accepted 25 Aug 2023
DOI: https://doi.org/10.26584/RDPA.2023.08.7.2.87

Hydration Effects of Water or Sports Beverages on the Peripheral Markers of Blood-Brain Barrier Integrity During Endurance Exercises at High Ambient Temperatures

Hee-Tae Roh1 ; Hyung-Il Lee2 ; Su-Youn Cho3, *
1Sun Moon University, Republic of Korea, Professor
2Sun Moon University, Republic of Korea, Professor
3Yonsei University, Republic of Korea, Research Professor

Correspondence to: *Email address: csy@yonsei.ac.kr

Abstract

This study aimed to investigate the fluid replacement effects of water or sports beverages on the peripheral markers of blood-brain barrier (BBB) integrity during endurance exercises at high ambient temperatures. Six healthy males were recruited and completed running trials in the following four conditions: 1) thermoneutral temperature at 18℃ (trial 18), 2) high ambient temperature at 32℃ without fluid replacement (trial 32), 3) high ambient temperature at 32℃ with water replacement (trial 32+W), and 4) high ambient temperature at 32℃ with sports beverage replacement (trial 32+S). Blood samples were collected pre-exercise, post-exercise, and 1-h post-exercise for each condition. In trial 32, hematocrit levels were significantly increased post-exercise than pre-exercise (p < 0.05). In all trials, the S100β levels were significantly increased post-exercise compared to pre-exercise (p < 0.05). Furthermore, the S100β levels were significantly decreased in all trials 1-h post-exercise than post-exercise (p < 0.05), and these levels were significantly higher 1-h post-exercise in trial 32 than in other trials (p < 0.05). In all trials, ammonia levels were significantly higher post-exercise than pre-exercise (p < 0.05). These results suggested that exercises at high ambient temperatures could damage the BBB more than exercises at thermoneutral temperatures. Additionally, water or sports beverage hydration during acute exercises at high ambient temperatures can effectively reduce BBB damage caused by exercise and thermal stress.

Keywords:

exercise, heat stress, blood-brain barrier, hydration, sports beverages

Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1F1A1063415). This article is a partly condensed form of the first author's doctoral thesis from Yonsei University.

References

  • American College of Sports Medicine., Sawka, M.N., Burke, L.M., Eichner, E.R., Maughan, R.J., Montain, S.J. & Stachenfeld, N.S. (2007). American College of Sports Medicine position stand. Exercise and fluid replacement. Med Sci Sports Exerc. 39(2):377-90.
  • Armstrong LE. (2021). Rehydration during Endurance Exercise: Challenges, Research, Options, Methods. Nutrients. 13(3):887. [https://doi.org/10.3390/nu13030887]
  • Banister, E.W. & Cameron, B.J. (1990). Exercise-induced hyperammonemia: peripheral and central effects. Int J Sports Med. 11(2):129-42. [https://doi.org/10.1055/s-2007-1024864]
  • Bassini-Cameron, A., Monteiro, A., Gomes, A., Werneck-de-Castro, J.P. & Cameron, L. (2008). Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way. Br J Sports Med. 42(4):260-6. [https://doi.org/10.1136/bjsm.2007.040378]
  • Belval LN, Hosokawa Y, Casa DJ, Adams WM, Armstrong LE, Baker LB, Burke L, Cheuvront S, Chiampas G, González-Alonso J, Huggins RA, Kavouras SA, Lee EC, McDermott BP, Miller K, Schlader Z, Sims S, Stearns RL, Troyanos C, Wingo J. (2019). Practical Hydration Solutions for Sports. Nutrients. 11(7):1550. [https://doi.org/10.3390/nu11071550]
  • Blomstrand E. (2001). Amino acids and central fatigue. Amino Acids. 20(1):25-34. [https://doi.org/10.1007/s007260170063]
  • Brooks, G.A., Fahey, T.D. & Baldwin, K.M. (2005). Exercise physiology: Human Bioenergetics and Its Applications. McGraw-Hill. New York.
  • Bruce, R.A., Blackmon, J.R., Jones, J.W. & Strait, G. (1963). Exercising testing in adult normal subjects and cardiac patients. Pediatrics. 32(4):742-756. [https://doi.org/10.1542/peds.32.4.742]
  • Caruso, J.F., McLagan, J.R., Olson, N.M., Shepherd, C.M., Taylor, S.T. & Emel, T.J. (2009). beta(2)-Adrenergic agonist administration and strength training. Phys Sportsmed. 37(2):66-73. [https://doi.org/10.3810/psm.2009.06.1711]
  • Coqueiro AY, Rogero MM, Tirapegui J. (2019). Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition. Nutrients. 11(4):863. [https://doi.org/10.3390/nu11040863]
  • Davson, H., Zlokovic, B., Rakic, L. & Segal, M.B. (2007). An Introduction to the Blood-Brain Barrier. CRC Pr I Llc. Boca Raton.
  • Doohan MA, Watzek JT, King N, White MJ, Stewart IB. (2023). Does increased core temperature alter cognitive performance during exercise-induced heat strain? A narrative review. J Appl Physiol. 135(1):35-52. [https://doi.org/10.1152/japplphysiol.00070.2023]
  • Dudley, G.A., Abraham, W.M. & Terjung, R.L. (1982). Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. J Appl Physiol. 53(4):844-50. [https://doi.org/10.1152/jappl.1982.53.4.844]
  • Elosegui S, López-Seoane J, Martínez-Ferrán M, Pareja-Galeano H. (2022). Interaction Between Caffeine and Creatine When Used as Concurrent Ergogenic Supplements: A Systematic Review. Int J Sport Nutr Exerc Metab. 32(4):285-295. [https://doi.org/10.1123/ijsnem.2021-0262]
  • Eriksson, L.S., Broberg, S., Björkman, O. & Wahren, J. (1985). Ammonia metabolism during exercise in man. Clin Physiol. 5(4):325-36. [https://doi.org/10.1111/j.1475-097X.1985.tb00753.x]
  • Friis T, Wikström AK, Acurio J, León J, Zetterberg H, Blennow K, Nelander M, Åkerud H, Kaihola H, Cluver C, Troncoso F, Torres-Vergara P, Escudero C, Bergman L. (2022). Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia. Cells. 11(5):789. [https://doi.org/10.3390/cells11050789]
  • Gopinathan, P.M., Pichan, G. & Sharma, V.M. (1988). Role of dehydration in heat stress-induced variations in mental performance. Arch Environ Health. 43(1):15-7. [https://doi.org/10.1080/00039896.1988.9934367]
  • Goulet, E.D. (2010). Glycerol-induced hyperhydration: a method for estimating the optimal load of fluid to be ingested before exercise to maximize endurance performance. J Strength Cond Res. 24(1):74-8. [https://doi.org/10.1519/JSC.0b013e3181bd43e2]
  • Grandjean, A.C. & Grandjean, N.R. (2007). Dehydration and cognitive performance. J Am Coll Nutr. 26(5):549-554. [https://doi.org/10.1080/07315724.2007.10719657]
  • Kim JW, So WY, Cha KS. (2017). Changes in Blood Lactate Levels after a 40-km Endurance March Depend on Fluid Replacements: A Case Study on Korean Military Academy Cadets. Iran J Public Health. 46(2):270-271.
  • Koh SX, Lee JK. (2014). S100B as a marker for brain damage and blood-brain barrier disruption following exercise. Sports Med. 44(3):369-85. [https://doi.org/10.1007/s40279-013-0119-9]
  • Lasek-Bal A, Jedrzejowska-Szypulka H, Student S, Warsz-Wianecka A, Zareba K, Puz P, Bal W, Pawletko K, Lewin-Kowalik J. (2019). The importance of selected markers of inflammation and blood-brain barrier damage for short-term ischemic stroke prognosis. J Physiol Pharmacol. 70(2). [https://doi.org/10.1101/503953]
  • López-Torres O, Rodríguez-Longobardo C, Capel-Escoriza R, Fernández-Elías VE. (2022). Ergogenic Aids to Improve Physical Performance in Female Athletes: A Systematic Review with Meta-Analysis. Nutrients. 15(1):81. [https://doi.org/10.3390/nu15010081]
  • MacLean, D.A., Spriet, L.L., Hultman, E. & Graham, T.E. (1991). Plasma and muscle amino acid and ammonia responses during prolonged exercise in humans. J Appl Physiol. 70(5):2095-103. [https://doi.org/10.1152/jappl.1991.70.5.2095]
  • Maughan RJ, Shirreffs SM, Watson P. (2007). Exercise, heat, hydration and the brain. J Am Coll Nutr. 26(5):604S-612S. [https://doi.org/10.1080/07315724.2007.10719666]
  • Mikulski T, Dabrowski J, Hilgier W, Ziemba A, Krzeminski K. (2015). Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men. Folia Neuropathol. 53(4):377-86. [https://doi.org/10.5114/fn.2015.56552]
  • Mündel T, King J, Collacott E, Jones DA. (2006). Drink temperature influences fluid intake and endurance capacity in men during exercise in a hot, dry environment. Exp Physiol. 91(5):925-33. [https://doi.org/10.1113/expphysiol.2006.034223]
  • Mündel T. (2008). Exercise heat stress and metabolism. Med Sport Sci. 53:121-129. [https://doi.org/10.1159/000151554]
  • Nadel, E.R., Mack, G.W. & Nose, H. (1990). Influence of fluid replacement beverages on body fluid homeostasis during exercise and recovery. Perspectives in Exercise Science and Sports Medicine. 3:181-205.
  • Paik, I.Y. (1999). Carbohydrate-Electrolyte Contained Drink Supplement on Exercise Performance and Blood Fatigue Induction Factors Change Following Intensive Endurance Running. The Korean Journal of Physical Education. 38(1):233-249.
  • Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. (2019). Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 99(1):21-78. [https://doi.org/10.1152/physrev.00050.2017]
  • Trangmar SJ, González-Alonso J. (2019). Heat, Hydration and the Human Brain, Heart and Skeletal Muscles. Sports Med. 49(1):69-85. [https://doi.org/10.1007/s40279-018-1033-y]
  • Varanoske AN, McClung HL, Sepowitz JJ, Halagarda CJ, Farina EK, Berryman CE, Lieberman HR, McClung JP, Pasiakos SM, Philip Karl J. (2022). Stress and the gut-brain axis: Cognitive performance, mood state, and biomarkers of blood-brain barrier and intestinal permeability following severe physical and psychological stress. Brain Behav Immun. 101:383-393. [https://doi.org/10.1016/j.bbi.2022.02.002]
  • Watson, P., Shirreffs, S.M. & Maughan, R.J. (2005). Blood-brain barrier integrity may be threatened by exercise in a warm environment. Am J Physiol Regul Integr Comp Physiol. 288(6):1689-94. [https://doi.org/10.1152/ajpregu.00676.2004]
  • Wilmore, J.H. & Costill, D.L. (2004). Physiology of Sport and Exercise. (3rd edition) Human Kinetics. Champaign.
  • Yun GS, In YN, Kang C, Park JS, You Y, Min JH, Ahn HJ, Yoo I, Kim SW, Oh SK, Lee IH, Kim DM. (2022). Development of a strategy for assessing blood-brain barrier disruption using serum S100 calcium-binding protein B and neuron-specific enolase in early stage of neuroemergencies: A preliminary study. Medicine. 101(28):e29644. [https://doi.org/10.1097/MD.0000000000029644]
  • Zaychik, Y., Fainstein, N., Touloumi, O., Goldberg, Y., Hamdi, L., Segal, S., Nabat, H., Zoidou, S., Grigoriadis, N., Katz, A., Ben-Hur, T., & Einstein, O. (2021). High-Intensity Exercise Training Protects the Brain Against Autoimmune Neuroinflammation: Regulation of Microglial Redox and Pro-inflammatory Functions. Frontiers in Cellular Neuroscience, 15, 640724. [https://doi.org/10.3389/fncel.2021.640724]